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M9480123.TXT
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1994-08-09
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Document 0123
DOCN M9480123
TI Circulating cytotoxic T lymphocyte precursors in maedi-visna
virus-infected sheep.
DT 9410
AU Blacklaws BA; Bird P; Allen D; McConnell I; Department of Veterinary
Pathology, University of Edinburgh,; Summerhall, U.K.
SO J Gen Virol. 1994 Jul;75 ( Pt 7):1589-96. Unique Identifier : AIDSLINE
MED/94292909
AB Maedi-visna virus (MVV)-specific cytotoxic T lymphocytes (CTL) were
detected, after in vitro culture with MVV antigen and recombinant human
interleukin-2, in the efferent lymph and peripheral blood of sheep
chronically infected with MVV. Cytotoxicity was mediated by CD8+
lymphocytes and was specific for particular strains of MVV. These
precursor CTL were detected in the blood between day 23 and day 100
after infection via the skin. In one out of seven persistently infected
sheep MVV-specific cytotoxicity was seen in uncultured peripheral blood
cells. Again the effector population consisted of CD8+ lymphocytes. The
only other viral infections in which CTL have been detected in
peripheral blood mononuclear cells prior to secondary stimulation are
those caused by the simian and human immunodeficiency viruses.
DE Animal Antigens, CD8/ANALYSIS Cells, Cultured Cytotoxicity,
Immunologic/DRUG EFFECTS/*IMMUNOLOGY Disease Models, Animal Human HIV
Infections/IMMUNOLOGY Interleukin-2/PHARMACOLOGY Leukocytes,
Mononuclear Lymph/CYTOLOGY Pneumonia, Progressive Interstitial, of
Sheep/*IMMUNOLOGY/ MICROBIOLOGY Sheep Simian Acquired
Immunodeficiency Syndrome/IMMUNOLOGY Skin Support, Non-U.S. Gov't
T-Lymphocyte Subsets/IMMUNOLOGY T-Lymphocytes, Cytotoxic/*IMMUNOLOGY
Visna-Maedi Virus/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).